Publications

  • Au FKC, Hau BKT, Qi RZ. Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction. J Cell Biol. 2020 May 4;219(5):e201909094. doi: 10.1083/jcb.201909094.
  • Chan KH, Tse LH, Huang X, Wong YH. Molecular basis defining the selectivity of substituted isoquinolinones for the melatonin MT2 Biochem Pharmacol. 2020 Jul;177:114020. doi: 10.1016/j.bcp.2020.114020.
  • Chen WW, Fu WY, Su YT, Fang WQ, Fu AKY, Ip NY. Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect. Sci Rep. 2019 Feb 4;9(1):1190. doi: 10.1038/s41598-018-38103-3.
  • Chen Y, Fu AKY, Ip NY. Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies. Pharmacol Ther. 2019 Mar;195:186-198.
  • Chen Y, Xu J, Zhou X, Liu S, Zhang Y, Ma S, Fu AKY, Ip NY, Chen Y. Changes of protein phosphorylation are associated with synaptic functions during the early stage of Alzheimer's Disease. ACS Chem Neurosci. 2019 Sep 18;10(9):3986-3996.
  • Cheung PP, Jiang B, Booth GT, Chong TH, Unarta IC, Wang Y, Suarez GD, Wang J, Lis JT, Huang X. Identifying Transcription Error-Enriched Genomic Loci Using Nuclear Run-on Circular-Sequencing Coupled with Background Error Modeling. J Mol Biol. 2020 Jun 12;432(13):3933-3949. doi: 10.1016/j.jmb.2020.04.011.
  • Fu WY, Wang X, Ip NY. Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities. ACS Chem Neurosci. 2019 Feb 20;10(2):872-879. doi: 10.1021/acschemneuro.8b00402.
  • He S, Tian Y, Feng S, Wu Y, Shen X, Chen K, He Y, Sun Q, Li X, Xu J, Wen Z, Qu JY. In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy. eLife. 2020 Jan 6;9:e52024. doi: 10.7554/eLife.52024.
  • He S, Wei X, Qin Z, Chen C, Wu Z, Qu JY. In vivo study of metabolic dynamics and heterogeneity in brown and beige fat by label-free multiphoton redox and fluorescence lifetime microscopy. J Biophotonics. 2020 Feb;13(2):e201960057. doi: 10.1002/jbio.201960057.
  • He S, Xu J, Qu JY, Wen Z. Lightening the way of hematopoiesis: Infrared laser-mediated lineage tracing with high spatial-temporal resolution. Exp Hematol. 2020 May 10;85:3-7. doi: 10.1016/j.exphem.2020.04.009.
  • Hu WH, Chan GK, Duan R, Wang HY, Kong XP, Dong TT, Tsim KW. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 2019 Nov 20;11(12):1828. doi: 10.3390/cancers11121828.
  • Hu WH, Wang HY, Kong XP, Xiong QP, Poon KK, Xu L, Duan R, Chan GK, Dong TT, Tsim KW. Polydatin suppresses VEGF-induced angiogenesis through binding with VEGF and inhibiting its receptor signaling. FASEB J. 2019 Jan;33(1):532-544. doi: 10.1096/fj.201800750R.
  • Huang Y, Kwan KKL, Leung KW, Yao P, Wang H, Dong TT, Tsim KWK. Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents. J Ginseng Res. 2019 Oct;43(4):517-526. doi: 10.1016/j.jgr.2018.02.002.
  • Kong XP, Liu EYL, Chen ZC, Xu ML, Yu AXD, Wu QY, Xia YJ, Duan R, Dong TTX, Tsim KWK. Synergistic inhibition of acetylcholinesterase by alkaloids derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex. Molecules. 2019 Dec 13;24(24):4567. doi: 10.3390/molecules24244567.
  • Lau SF, Chen C, Fu WY, Qu JY, Cheung TH, Fu AKY, Ip NY. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer's Disease. Cell Rep. 2020 Apr 21;31(3):107530. doi: 10.1016/j.celrep.2020.107530.
  • Lei J, Sheng G, Cheung PP, Wang S, Li Y, Gao X, Zhang Y, Wang Y, Huang X. Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A. 2019 Jan;116(3):845-853. doi: 10.1073/pnas.1817041116.
  • Lin L, Lyu Q, Kwan PY, Zhao J, Fan R, Chai A, Lai CSW, Chan YS, Shen X, Lai KO. The epilepsy and intellectual disability-associated protein TBC1D24 regulates the maintenance of excitatory synapses and animal behaviors. PLoS Genet. 2020 Jan 31;16(1):e1008587. doi: 10.1371/journal.pgen.1008587.
  • Liu EYL, Xia Y, Kong X, Guo MSS, Yu AXD, Zheng BZY, Mak S, Xu ML, Tsim KWK. Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages. Acta Pharm Sin B. 2020 May 29. doi: 10.1016/j.apsb.2020.05.005.
  • Liu EYL, Xu ML, Xia Y, Kong X, Wu Q, Dong TTX, Tsim KWK. Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells. Chem Biol Interact. 2019 Jun 1;306:147-151. doi: 10.1016/j.cbi.2019.04.031.
  • Liu Z, Yang Y, Gu A, Xu J, Mao Y, Lu H, Hu W, Lei QY, Li Z, Zhang M, Cai Y, Wen W. Par complex cluster formation mediated by phase separation. Nat Commun. 2020 May 08;11(1):2266. doi: 10.1038/s41467-020-16135-6.
  • Lo LH, Dong R, Lyu Q, Lai KO. The protein arginine methyltransferase PRMT8 and substrate G3BP1 control Rac1-PAK1 signaling and actin cytoskeleton for dendritic spine maturation. Cell Rep. 2020 Jun 9;31(10):107744. doi: 10.1016/j.celrep.2020.107744.
  • Lo LH, Lai KO. Dysregulation of protein synthesis and dendritic spine morphogenesis in ASD: studies in human pluripotent stem cells. Mol Autism. 2020 May 27;11(1):40. doi: 10.1186/s13229-020-00349-y.
  • Pan C, Liu C, Peng J, Ren P, Huang X. Three‐site and five‐site fixed‐charge water models compatible with AMOEBA force field. J Comput Chem. 2020 Jan 24;41:1034–1044. doi: 10.1002/jcc.26151.
  • Qin Z, He S, Yang C, Yung JS, Chen C, Leung CK, Liu K, Qu JY. Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo. Light Sci Appl. 2020 May 06;9:79. doi: 10.1038/s41377-020-0317-9.
  • Shen Y, Wang K, Qi RZ. The catalytic subunit of DNA polymerase δ is a nucleocytoplasmic shuttling protein. Exp Cell Res. 2019 Feb 15;375(2):36-40. doi: 10.1016/j.yexcr.2019.01.003.
  • Su YT, Lau SF, Ip JPK, Cheung K, Cheung THT, Fu AKY, Ip NY. α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13651-13660. doi: 10.1073/pnas.1903891116.
  • Tse CKM, Xu J, Xu L, Sheong FK, Wang S, Chow HY, Gao X, Li X, Cheung PP, Wang D, Zhang Y, Huang X. Intrinsic Cleavage of RNA Polymerase II Adopts a Nucleobase-independent Mechanism Assisted by Transcript Phosphate. Nat Energy. 2019 Mar;2(3):228-235. doi: 10.1038/s41929-019-0227-5.
  • Tse LH, Wong YH. GPCRs in Autocrine and Paracrine Regulations. Front Endocrinol (Lausanne). 2019 July 12;10:428. doi: 10.3389/fendo.2019.00428.
  • van de Willige D, Hummel JJ, Alkemade C, Kahn OI, Au FK, Qi RZ, Dogterom M, Koenderink GH, Hoogenraad CC, Akhmanova A. Cytolinker Gas2L1 regulates axon morphology through microtubule-modulated actin stabilization. EMBO Rep. 2019 Nov 5;20(11):e47732. doi: 10.15252/embr.201947732.
  • Wang J, Zhang C, Feng B. The rapidly advancing Class 2 CRISPR-Cas technologies: A customizable toolbox for molecular manipulations. J Cell Mol Med. 2020 Mar;24(6):3256–3270.
  • Wang X, Ye F, Wen Z, Guo Z, Yu C, Huang WK, Rojas Ringeling F, Su Y, Zheng W, Zhou G, Christian KM, Song H, Zhang M, Ming GL. Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. Mol Psychiatry. 2019 August 23. doi: 10.1038/s41380-019-0485-2.
  • Xu ML, Zheng ZY, Xia YJ, Liu EY, Chan SK, Hu WH, Duan R, Dong TT, Zhan CS, Shang XH, Tsim KW. Shexiang Baoxin Pill, a formulated Chinese herbal mixture, induces neuronal differentiation of PC12 cells: a signaling triggered by activation of protein kinase A. Front Pharmacol. 2019 Oct 9;10:1130. doi: 10.3389/fphar.2019.01130.
  • Yu AX, Xu ML, Yao P, Kwan KK, Liu YX, Duan R, Dong TT, Ko RK, Tsim KW. Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways. FASEB J. 2020 Mar;34(3):4311-4328. doi: 10.1096/fj.201902319RRR.
  • Zhao J, Fok AHK, Fan R, Kwan PY, Chan HL, Lo LHY, Chan YS, Yung WH, Huang J, Lai CSW, Lai KO. Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory. eLife. 2020 Jan 21;9:e53456. doi: 10.7554/eLife.53456.
  • Zhang Z, Zheng X, Sun W, Peng Y, Guo Y, Lu D, Zheng Y, Li X, Jendrichovsky P, Tang P, He L, Li M, Liu Q, Xu F, Ng G, Chen X, He J. Visuoauditory associative memory established with cholecystokinin under anesthesia is retrieved in behavioral contexts. J Neurosci. 2020 Mar 4; 40(10):2025-2037.
  • Zhou X, Chen Y, Ip FC, Lai NC, Li YY, Jiang Y, Zhong H, Chen Y, Zhang Y, Ma S, Lo RM, Cheung K, Tong EP, Ko H, Shoai M, Mok KY, Hardy J, Mok VC, Kwok TC, Fu AK, Ip NY. Genetic and polygenic risk score analysis for Alzheimer’s disease in the Chinese population. Alzheimers Dement (Amst). 2020 (in press).
  • Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY. Non-coding variability at the APOE locus contributes to the Alzheimer's risk. Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z.